Increased risk of essential tremor in first‐degree relatives of patients with Parkinson's disease
Identifieur interne : 000331 ( France/Analysis ); précédent : 000330; suivant : 000332Increased risk of essential tremor in first‐degree relatives of patients with Parkinson's disease
Auteurs : Walter A. Rocca [États-Unis] ; James H. Bower [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Alexis Elbaz [États-Unis, France] ; Brandon R. Grossardt [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Daniel J. Schaid [États-Unis] ; Demetrius M. Maraganore [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Aggregation, Cohort Studies, Cohort study, Confidence Intervals, Essential Tremor (epidemiology), Essential Tremor (etiology), Essential Tremor (genetics), Family Health, Female, Human, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Proportional Hazards Models, Retrospective Studies, Risk, Risk factor, Sex Factors, Tremor, cohort study, essential tremor, familial aggregation, genetics.
- MESH :
- complications : Parkinson Disease.
- epidemiology : Essential Tremor, Parkinson Disease.
- etiology : Essential Tremor.
- genetics : Essential Tremor, Parkinson Disease.
- mix :
Abstract
We conducted a historical cohort study of 981 first‐degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first‐degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first‐degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records‐linkage system (family study method). In the population‐based sample, the risk of ET was significantly increased for relatives of patients with onset of PD ≤ 66 years (first tertile; hazard ratio [HR] = 2.24; 95% confidence interval [95% CI] = 1.26–3.98; P = 0.006). In the referral‐based sample, the risk of ET among relatives increased with younger onset of PD in patients (linear trend; P = 0.001), and was higher in relatives of PD patients with the tremor‐predominant or mixed form when compared with relatives of patients with the akinetic‐rigid form, and in men compared with women. These findings suggest that PD and ET may share familial susceptibility factors. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/7402A0EFE736CB6B93E2AC553C18D3077A493ACC/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00180121
DOI: 10.1002/mds.21584
Affiliations:
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ISTEX:7402A0EFE736CB6B93E2AC553C18D3077A493ACCLe document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-08-15">2007-08-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1607">1607</biblScope><biblScope unit="page" to="1614">1614</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7402A0EFE736CB6B93E2AC553C18D3077A493ACC</idno><idno type="DOI">10.1002/mds.21584</idno><idno type="ArticleID">MDS21584</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aggregation</term><term>Cohort Studies</term><term>Cohort study</term><term>Confidence Intervals</term><term>Essential Tremor (epidemiology)</term><term>Essential Tremor (etiology)</term><term>Essential Tremor (genetics)</term><term>Family Health</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Risk</term><term>Risk factor</term><term>Sex Factors</term><term>Tremor</term><term>cohort study</term><term>essential tremor</term><term>familial aggregation</term><term>genetics</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Agrégation</term><term>Etude cohorte</term><term>Facteur risque</term><term>Homme</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords><keywords scheme="mix" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Confidence Intervals</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson's disease</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term><term>Risk</term><term>Sex Factors</term><term>cohort study</term><term>essential tremor</term><term>familial aggregation</term><term>genetics</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">We conducted a historical cohort study of 981 first‐degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first‐degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first‐degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records‐linkage system (family study method). In the population‐based sample, the risk of ET was significantly increased for relatives of patients with onset of PD ≤ 66 years (first tertile; hazard ratio [HR] = 2.24; 95% confidence interval [95% CI] = 1.26–3.98; P = 0.006). In the referral‐based sample, the risk of ET among relatives increased with younger onset of PD in patients (linear trend; P = 0.001), and was higher in relatives of PD patients with the tremor‐predominant or mixed form when compared with relatives of patients with the akinetic‐rigid form, and in men compared with women. These findings suggest that PD and ET may share familial susceptibility factors. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Minnesota</li><li>Île-de-France</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name></region><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R." last="Grossardt">Brandon R. Grossardt</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name></country><country name="France"><region name="Île-de-France"><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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